Although methotrexate for autoimmune diseases is taken in lower doses than it is for cancer, side effects such as hair loss, nausea, headaches, and skin pigmentation are methotrexate 10 mg side effects methotrexate tiredness methotrexate toxicity treatment methotrexate still common .  Use of methotrexate methotrexate together with NSAIDS is safe, if adequate monitoring is done . Because of its effectiveness, low-dose methotrexate methotrexate is now first-line therapy for the treatment of rheumatoid arthritis .  Although originally designed as a chemotherapy drug (using high doses), in low methotrexate doses, methotrexate is a generally safe and well tolerated drug in the treatment of certain autoimmune diseases . Weekly doses are beneficial for 12 to 52 weeks duration therapy, although discontinuation rates are as high as 16% due to methotrexate adverse effects . It is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, lupus, sarcoidosis, Crohn's disease (although a recent review can you drink alcohol with methotrexate methotrexate what is it do you take methotrexate with food has raised the point that it is fairly underused in Crohn's disease), eczema and many forms of vasculitis .
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